Pub. Date : 2021 Jan 25
PMID : 33350984
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90. | echinatin | NLR family, pyrin domain containing 3 | Mus musculus |
| 2 | In this study, we showed that echinatin, the ingredient of the traditional herbal medicine licorice, effectively suppresses the activation of NLRP3 inflammasome in vitro and in vivo. | echinatin | NLR family, pyrin domain containing 3 | Mus musculus |
| 3 | Further investigation revealed that echinatin exerts its inhibitory effect on NLRP3 inflammasome by binding to heat-shock protein 90 (HSP90), inhibiting its ATPase activity, and disrupting the association between the cochaperone SGT1 and HSP90-NLRP3. | echinatin | NLR family, pyrin domain containing 3 | Mus musculus |
| 4 | Further investigation revealed that echinatin exerts its inhibitory effect on NLRP3 inflammasome by binding to heat-shock protein 90 (HSP90), inhibiting its ATPase activity, and disrupting the association between the cochaperone SGT1 and HSP90-NLRP3. | echinatin | NLR family, pyrin domain containing 3 | Mus musculus |
| 5 | Importantly, in vivo experiments demonstrated that administration of echinatin obviously inhibits NLRP3 inflammasome activation and ameliorates LPS-induced septic shock and DSS-induced colitis in mice. | echinatin | NLR family, pyrin domain containing 3 | Mus musculus |
| 6 | Collectively, our study identified echinatin as a novel inhibitor of NLRP3 inflammasome and may be developed as a potentially therapeutic approach for the treatment of NLRP3-driven diseases. | echinatin | NLR family, pyrin domain containing 3 | Mus musculus |
| 7 | Collectively, our study identified echinatin as a novel inhibitor of NLRP3 inflammasome and may be developed as a potentially therapeutic approach for the treatment of NLRP3-driven diseases. | echinatin | NLR family, pyrin domain containing 3 | Mus musculus |