Pub. Date : 2021 Feb
PMID : 33348024
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Multiple microRNAs regulate tacrolimus metabolism through CYP3A5. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | The CYP3A5 gene polymorphism accounts for the majority of inter-individual variability in tacrolimus pharmacokinetics. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | We found that the basal expression of CYP3A5 in donor grafts also played a significant role in tacrolimus metabolism under the same genetic conditions after pediatric liver transplantation. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 4 | We found that these miRNAs inhibited tacrolimus metabolism that was dependent on CYP3A5. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 5 | Luciferase reporter assays and functional studies showed that miR-26b-5p inhibited tacrolimus metabolism by directly regulating CYP3A5, while miR-29a-5p, miR-99a-5p, and miR-532-5p targeted HNF4alpha, NR1I3, and NR1I2, respectively, in turn regulating the downstream expression of CYP3A5; the corresponding target gene siRNAs markedly abolished the effects caused by miRNA inhibitors. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |