Pub. Date : 2021 Jan 19
PMID : 33347888
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The G2 loop and Switch I at the effector lobe of the catalytic domain exhibit large conformational changes in both the GDP- and GTP-bound systems, but in the GTP-bound Cdc42 the Switch I interactions with GTP are retained. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 2 | We propose that the differences are due to a network of hydrogen bonds that gets disrupted when Cdc42 is bound to GDP, a disruption that does not exist in other Rho GTP-ases. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |