Title : 7,3',4'-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses α-Melanocyte-Stimulating Hormone-Induced Melanogenesis by Targeting Melanocortin 1 Receptor.

Pub. Date : 2020

PMID : 33344501






2 Functional Relationships(s)
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1 Here, we found that 7,3",4"-THIF, but not daidzein, inhibited alpha-melanocyte-stimulating hormone (MSH)-induced intracellular and extracellular melanin production in B16F10 cells by directly targeting melanocortin 1 receptor (MC1R). Melanins proopiomelanocortin Homo sapiens
2 Moreover, 7,3",4"-THIF inhibited alpha-MSH-induced intracellular melanin production in human epidermal melanocytes (HEMs). Melanins proopiomelanocortin Homo sapiens