Title : Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats.

Pub. Date : 2021 Feb

PMID : 33341652






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1 In support of this, aged, laparotomized, and morphine-treated rats exhibited increased gene expression of various proinflammatory markers (IL-1beta, IL-6, TNFalpha, NLRP3, HMGB1, TLR2, and TLR4) in the hippocampus at the 2-week time point. Morphine tumor necrosis factor Rattus norvegicus