Pub. Date : 2020
PMID : 33335690
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapid GDP/GTP exchange in the packet of Rab5 sustains its high activity for promoting cancer progression. | Guanosine Diphosphate | RAB5A, member RAS oncogene family | Homo sapiens |
| 2 | Herein, we reported the discovery of a novel Rab5 inhibitor, neoandrographolide (NAP), by using high-throughput virtual screening with a natural product library containing 7459 compounds, which can occupy the surface groove of Rab5, competing with GDP/GTP for the binding. | Guanosine Diphosphate | RAB5A, member RAS oncogene family | Homo sapiens |
| 3 | Herein, we reported the discovery of a novel Rab5 inhibitor, neoandrographolide (NAP), by using high-throughput virtual screening with a natural product library containing 7459 compounds, which can occupy the surface groove of Rab5, competing with GDP/GTP for the binding. | Guanosine Diphosphate | RAB5A, member RAS oncogene family | Homo sapiens |
| 4 | Ser34 is the most important residue in the groove of Rab5, as it forms most hydrogen-bond interactions with GDP/GTP or NAP, and in silico mutation of Ser34 decreased the stabilization of Rab5. | Guanosine Diphosphate | RAB5A, member RAS oncogene family | Homo sapiens |
| 5 | Ser34 is the most important residue in the groove of Rab5, as it forms most hydrogen-bond interactions with GDP/GTP or NAP, and in silico mutation of Ser34 decreased the stabilization of Rab5. | Guanosine Diphosphate | RAB5A, member RAS oncogene family | Homo sapiens |
| 6 | This finding firstly identifies NAP as a novel inhibitor of Rab5, which directly binds with Rab5 by occupying the GDP/GTP binding groove to suppress its functions, highlighting a great potential of NAP to be developed as a chemotherapeutic agent in cancer therapy. | Guanosine Diphosphate | RAB5A, member RAS oncogene family | Homo sapiens |
| 7 | This finding firstly identifies NAP as a novel inhibitor of Rab5, which directly binds with Rab5 by occupying the GDP/GTP binding groove to suppress its functions, highlighting a great potential of NAP to be developed as a chemotherapeutic agent in cancer therapy. | Guanosine Diphosphate | RAB5A, member RAS oncogene family | Homo sapiens |