PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33335690-2	2020	Rapid GDP/GTP exchange in the packet of Rab5 sustains its high activity for promoting cancer progression.	Guanosine Diphosphate	6-9	RAB5A, member RAS oncogene family	Homo sapiens	40-44	
33335690-4	2020	Herein, we reported the discovery of a novel Rab5 inhibitor, neoandrographolide (NAP), by using high-throughput virtual screening with a natural product library containing 7459 compounds, which can occupy the surface groove of Rab5, competing with GDP/GTP for the binding.	Guanosine Diphosphate	248-251	RAB5A, member RAS oncogene family	Homo sapiens	45-49	
33335690-4	2020	Herein, we reported the discovery of a novel Rab5 inhibitor, neoandrographolide (NAP), by using high-throughput virtual screening with a natural product library containing 7459 compounds, which can occupy the surface groove of Rab5, competing with GDP/GTP for the binding.	Guanosine Diphosphate	248-251	RAB5A, member RAS oncogene family	Homo sapiens	227-231	
33335690-5	2020	Ser34 is the most important residue in the groove of Rab5, as it forms most hydrogen-bond interactions with GDP/GTP or NAP, and in silico mutation of Ser34 decreased the stabilization of Rab5.	Guanosine Diphosphate	108-111	RAB5A, member RAS oncogene family	Homo sapiens	53-57	
33335690-5	2020	Ser34 is the most important residue in the groove of Rab5, as it forms most hydrogen-bond interactions with GDP/GTP or NAP, and in silico mutation of Ser34 decreased the stabilization of Rab5.	Guanosine Diphosphate	108-111	RAB5A, member RAS oncogene family	Homo sapiens	187-191	
33335690-8	2020	This finding firstly identifies NAP as a novel inhibitor of Rab5, which directly binds with Rab5 by occupying the GDP/GTP binding groove to suppress its functions, highlighting a great potential of NAP to be developed as a chemotherapeutic agent in cancer therapy.	Guanosine Diphosphate	114-117	RAB5A, member RAS oncogene family	Homo sapiens	60-64	
33335690-8	2020	This finding firstly identifies NAP as a novel inhibitor of Rab5, which directly binds with Rab5 by occupying the GDP/GTP binding groove to suppress its functions, highlighting a great potential of NAP to be developed as a chemotherapeutic agent in cancer therapy.	Guanosine Diphosphate	114-117	RAB5A, member RAS oncogene family	Homo sapiens	92-96