Title : Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma.

Pub. Date : 2021 Feb

PMID : 33334586






1 Functional Relationships(s)
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1 Compounds 29b, 29c and 29a exhibited potent inhibitory activities towards VEGFR-2 at IC50 values of 3.1 +- 0.04, 3.4 +- 0.05 and 3.7 +- 0.06 microM, respectively, comparing sorafenib (IC50 = 2.4 +- 0.05 microM). Sorafenib kinase insert domain receptor Homo sapiens