Pub. Date : 2021 Nov 11
PMID : 33330868
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies. | Sulfhydryl Compounds | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 2 | We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection. | Sulfhydryl Compounds | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 3 | We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection. | Sulfhydryl Compounds | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 4 | One Sentence Summary: Thiol-based drugs decrease binding of SARS-CoV-2 spike protein to its receptor and inhibit SARS-CoV-2 cell entry. | Sulfhydryl Compounds | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |