PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33330868-0 2021 Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies. Sulfhydryl Compounds 59-64 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 22-27 33330868-4 2021 We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection. Sulfhydryl Compounds 14-19 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 140-145 33330868-4 2021 We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection. Sulfhydryl Compounds 14-19 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 215-220 33330868-6 2021 One Sentence Summary: Thiol-based drugs decrease binding of SARS-CoV-2 spike protein to its receptor and inhibit SARS-CoV-2 cell entry. Sulfhydryl Compounds 22-27 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 71-76