Title : Irisin Protects Against Motor Dysfunction of Rats with Spinal Cord Injury via Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase-Nuclear Factor Kappa-B Pathway.

Pub. Date : 2020

PMID : 33312127






2 Functional Relationships(s)
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1 Further biochemical analyses showed that irisin inhibited SCI-induced overexpression of Interleukin-1beta (IL-1beta), Interleukin- 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), inducible nitricoxidesynthase (iNOS) and Cyclooxygenase-2 (COX-2)], as well as nuclear factor kappa-B (NF-kappaB)p65 in rats, and the positive function of irisin could be reversed by Compound C treatment. irisin nitric oxide synthase 2 Rattus norvegicus
2 In our in vitro study, LPS-induced declines of cell viability and neurite length of PC12 cell were inhibited by irisin treatment, and irisin inhibited LPS-induced overexpression of NF-kappaBp65, IL-1beta, IL-6, TNF-alpha, iNOS and COX-2. irisin nitric oxide synthase 2 Rattus norvegicus