Pub. Date : 2020 Dec 11
PMID : 33306006
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin acts as a P-gp modulator via impeding signal transduction from nucleotide-binding domain to transmembrane domain. | Quercetin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Among them, quercetin has revealed a great potential to modulate P-gp activity. | Quercetin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | In the present work, we showed that quercetin binds in the interacting region between the transmembrane domain and nucleotide-binding domain out of the three plausible binding sites of P-gp and restrict the conformational change from inward- to outward-facing conformation of P-gp. | Quercetin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | In the present work, we showed that quercetin binds in the interacting region between the transmembrane domain and nucleotide-binding domain out of the three plausible binding sites of P-gp and restrict the conformational change from inward- to outward-facing conformation of P-gp. | Quercetin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Our work reveals the mechanistic understanding of quercetin induced modulation of P-gp and indicates its importance in cancer treatment. | Quercetin | ATP binding cassette subfamily B member 1 | Homo sapiens |