Title : Protective Effects of Low Dose Vorinostat on Cisplatin-Induced Nephrotoxicity in Rats.

Pub. Date : 2021 Oct 25

PMID : 33297925






1 Functional Relationships(s)
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1 RESULTS: Administration of CDDP single dose (7.5 mg/kg IP) 5 days before the end of the experiment (at day 23) produced a significant decrease in renal glutathione levels and a significant increase in serum urea nitrogen, creatinine, renal malondialdehyde, tumor necrosis factor-alpha, tumor suppressor protein (p53) and nuclear factor kappa B levels compared to the control group. Cisplatin tumor necrosis factor Rattus norvegicus