Title : PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter-Individual Variability.

Pub. Date : 2021 Feb

PMID : 33289952






2 Functional Relationships(s)
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1 Application of PBPK model for coproporphyrin I to evaluate the impact of SLCO1B1 genotype, ethnicity, and sex on its inter-individual variability. coproporphyrin I solute carrier organic anion transporter family member 1B1 Homo sapiens
2 Lower magnitude of CPI-drug interaction was simulated in 521CC subjects, suggesting the risk of under-estimation of CPI-drug interaction without prior OATP1B1 genotyping. coproporphyrin I solute carrier organic anion transporter family member 1B1 Homo sapiens