Title : Krill oil extract inhibits the migration of human colorectal cancer cells and down-regulates EGFR signalling and PD-L1 expression.

Pub. Date : 2020 Dec 7

PMID : 33287803






2 Functional Relationships(s)
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1 At the molecular level, krill oil extract reduced the expression of EGFR, pEGFR (P < 0.001 for both) and their downstream signalling, pERK1/2 and pAKT (P < 0.01 to P < 0.001) without altering total ERK 1/2 and AKT levels. krill oil mitogen-activated protein kinase 3 Homo sapiens
2 The potential anti-cancer properties of krill oil are likely to be associated with the downregulation of EGFR, pEGFR and their downstream pERK/ERK1/2 and pAKT/AKT signalling pathways along with the downregulation of PD-L1. krill oil mitogen-activated protein kinase 3 Homo sapiens