Title : Increased sensitivity of BCR-ABL-induced B-ALL to imatinib by releasing leukemia B cell differentiation blockage.

Pub. Date : 2020

PMID : 33284894






1 Functional Relationships(s)
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1 We aimed to investigate whether it was possible to promote pro/pre-B cell maturation beyond this phase and make them sensitive to imatinib treatment by overexpressing immunoregulatory tyrosine activation motif (ITAM) with BCR-ABL in a Ph+ B-ALL mouse model. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens