Title : NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis.

Pub. Date : 2020 Dec 2

PMID : 33276631






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 NF-E2 p45-related factor 2 (NRF2, encoded in the human by NFE2L2) mediates short-term adaptation to thiol-reactive stressors. Sulfhydryl Compounds NFE2 like bZIP transcription factor 2 Homo sapiens
2 NF-E2 p45-related factor 2 (NRF2, encoded in the human by NFE2L2) mediates short-term adaptation to thiol-reactive stressors. Sulfhydryl Compounds NFE2 like bZIP transcription factor 2 Homo sapiens
3 NF-E2 p45-related factor 2 (NRF2, encoded in the human by NFE2L2) mediates short-term adaptation to thiol-reactive stressors. Sulfhydryl Compounds NFE2 like bZIP transcription factor 2 Homo sapiens
4 In normal cells, activation of NRF2 by a thiol-reactive stressor helps prevent, for a limited period of time, the initiation of cancer by chemical carcinogens through induction of genes encoding drug-metabolising enzymes. Sulfhydryl Compounds NFE2 like bZIP transcription factor 2 Homo sapiens