Pub. Date : 2021 Feb
PMID : 33273059
2 Functional Relationships(s)Download |
||||||
Sentence | Compound Name | Protein Name | Organism |
|||
1 | In vitro, AZD0364 treatment resulted in inhibition of proximal and distal biomarkers and reduced proliferation in sensitive BRAF mutant and KRAS mutant cell lines. | N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens | ||
2 | In multiple in vivo xenograft models, AZD0364 showed dose and time-dependent modulation of ERK1/2-dependent signalling biomarkers resulting in tumour regression in sensitive BRAF and KRAS mutant xenografts. | N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |