Title : Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway.

Pub. Date : 2021 Feb

PMID : 33259938






1 Functional Relationships(s)
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1 Our further experiments in both animal and cell culture work has found that the level of IkappaBalpha(Inhibitor of NF-kappaB) were decreased and the nuclear level of NF-kappaB p65 of renal tubular cells were increased after cisplatin injury while VDR activation by paricalcitol could reverse up-regulation of nuclear NF-kappaB p65 with reduced cell pyroptosis. paricalcitol nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus