Title : Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non-expressors early after living donor kidney transplantation: Effect of interleukin 6-induced suppression of the cytochrome P450 3A gene.

Pub. Date : 2021 Mar

PMID : 33248001






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1 Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non-expressors early after living donor kidney transplantation: Effect of interleukin 6-induced suppression of the cytochrome P450 3A gene. Tacrolimus cytochrome P450 family 3 subfamily A member 5 Homo sapiens
2 The blood tacrolimus concentration per dose ratio (C/D) temporarily increased post-kidney transplantation on days 3 to 4 only in CYP3A5 non-expressors. Tacrolimus cytochrome P450 family 3 subfamily A member 5 Homo sapiens
3 We hypothesise that CYP3A5 non-expressors might exhibit a temporary decrease in the oral clearance of tacrolimus via an increase in serum IL-6 concentrations early after kidney transplantation. Tacrolimus cytochrome P450 family 3 subfamily A member 5 Homo sapiens