Pub. Date : 2021 Jan
PMID : 33247550
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells. | licochalcone A | epidermal growth factor receptor | Homo sapiens |
| 2 | Here, we reported the natural product, licochalcone A, exhibited a profound anti-tumour efficacy through directly targeting EGFR signalling. | licochalcone A | epidermal growth factor receptor | Homo sapiens |
| 3 | Licochalcone A inhibited in vitro cell growth, colony formation and in vivo tumour growth of either wild-type (WT) or activating mutation EGFR-expressed NSCLC cells. | licochalcone A | epidermal growth factor receptor | Homo sapiens |
| 4 | Licochalcone A bound with L858R single-site mutation, exon 19 deletion, L858R/T790M mutation and WT EGFR ex vivo, and impaired EGFR kinase activity both in vitro and in NSCLC cells. | licochalcone A | epidermal growth factor receptor | Homo sapiens |
| 5 | Licochalcone A bound with L858R single-site mutation, exon 19 deletion, L858R/T790M mutation and WT EGFR ex vivo, and impaired EGFR kinase activity both in vitro and in NSCLC cells. | licochalcone A | epidermal growth factor receptor | Homo sapiens |
| 6 | Mechanistically, we found that treatment with licochalcone A translationally suppressed survivin through inhibiting EGFR downstream kinases ERK1/2 and Akt. | licochalcone A | epidermal growth factor receptor | Homo sapiens |