Title : Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine.

Pub. Date : 2021 Jan

PMID : 33245982






1 Functional Relationships(s)
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1 SNI upregulated DNMTs and downregulated Bdnf and exon I in the hippocampus and induced depression behaviors, whereas blocking the upregulation of DNMTs with RG108 alleviated SNI-induced depression by up-regulation of the expression of Bdnf and exon I. RG108 brain-derived neurotrophic factor Rattus norvegicus