Title : MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection.

Pub. Date : 2020 Nov 17

PMID : 33245731






5 Functional Relationships(s)
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Protein Name
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1 In some human cells, remdesivir increases ACE2-promoter luciferase-reporter expression, ACE2 mRNA and protein, and ACE2 expression is attenuated by MEKi. remdesivir angiotensin converting enzyme 2 Homo sapiens
2 In some human cells, remdesivir increases ACE2-promoter luciferase-reporter expression, ACE2 mRNA and protein, and ACE2 expression is attenuated by MEKi. remdesivir angiotensin converting enzyme 2 Homo sapiens
3 In some human cells, remdesivir increases ACE2-promoter luciferase-reporter expression, ACE2 mRNA and protein, and ACE2 expression is attenuated by MEKi. remdesivir angiotensin converting enzyme 2 Homo sapiens
4 In serum-deprived and stimulated cells treated with remdesivir and MEKi we observed correlations between pRB, pERK, and ACE2 expression further supporting role of proliferative state and MAPK pathway in ACE2 regulation. remdesivir angiotensin converting enzyme 2 Homo sapiens
5 In serum-deprived and stimulated cells treated with remdesivir and MEKi we observed correlations between pRB, pERK, and ACE2 expression further supporting role of proliferative state and MAPK pathway in ACE2 regulation. remdesivir angiotensin converting enzyme 2 Homo sapiens