Title : Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation.

Pub. Date : 2021 Jun

PMID : 33244652

1 Functional Relationships(s)
Compound Name
Protein Name
1 Interestingly, although both isomers of RSV bind to TyrRS, only the cis-isomer evokes a unique structural change at the active site to promote its interaction with poly-ADP-ribose polymerase 1 (PARP1), a major determinant of cellular NAD+-dependent stress response. NAD poly(ADP-ribose) polymerase 1 Homo sapiens