Title : Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.

Pub. Date : 2020 Nov 26

PMID : 33243973






1 Functional Relationships(s)
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1 Using rescue experiments with a brain extracellular extract, and direct measurements, we demonstrate that cytosolic serine starvation controls cell movement by increasing reactive oxygen species formation and decreasing ATP levels, thereby promoting activation of the AMP sensor kinase (AMPK) by phosphorylation. Oxygen protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens