Pub. Date : 2020 Nov
PMID : 33243932
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4. | treg | C-C motif chemokine receptor 4 | Homo sapiens |
| 2 | In preclinical and clinical studies, it has been suggested that tumor trafficking of Treg is mediated by CC chemokine receptor 4 (CCR4). | treg | C-C motif chemokine receptor 4 | Homo sapiens |
| 3 | In preclinical and clinical studies, it has been suggested that tumor trafficking of Treg is mediated by CC chemokine receptor 4 (CCR4). | treg | C-C motif chemokine receptor 4 | Homo sapiens |
| 4 | Hence, CCR4 antagonism has the potential to be an effective antitumor treatment by reducing the accumulation of Treg into the tumor microenvironment (TME). | treg | C-C motif chemokine receptor 4 | Homo sapiens |
| 5 | METHODS: We developed in vitro and in vivo models to assess Treg migration and antitumor efficacy using a potent and selective CCR4 antagonist, CCR4-351. | treg | C-C motif chemokine receptor 4 | Homo sapiens |