Title : Rats deficient in the GAD65 isoform exhibit epilepsy and premature lethality.

Pub. Date : 2021 Feb

PMID : 33236473






3 Functional Relationships(s)
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Protein Name
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1 GABA is synthesized by glutamate decarboxylase (GAD), which has two isoforms, namely, GAD65 and GAD67, encoded by the Gad2 and Gad1 genes, respectively. gamma-Aminobutyric Acid glutamate-ammonia ligase Rattus norvegicus
2 GABA is synthesized by glutamate decarboxylase (GAD), which has two isoforms, namely, GAD65 and GAD67, encoded by the Gad2 and Gad1 genes, respectively. gamma-Aminobutyric Acid glutamate-ammonia ligase Rattus norvegicus
3 Our Western blot analysis demonstrated that the protein expression ratio of GAD65 to GAD67 in the brain was greater in rats than in mice during postnatal development, suggesting that the contribution of each GAD isoform to GABA functions differs between these two species. gamma-Aminobutyric Acid glutamate-ammonia ligase Rattus norvegicus