Title : Regulation of Skin Barrier Function via Competition between AHR Axis versus IL-13/IL-4‒JAK‒STAT6/STAT3 Axis: Pathogenic and Therapeutic Implications in Atopic Dermatitis.

Pub. Date : 2020 Nov 20

PMID : 33233866






1 Functional Relationships(s)
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1 Conventional and recently developed agents for treating AD such as steroid, calcineurin inhibitors, cyclosporine, dupilumab, and JAK inhibitors inhibit the IL-13/IL-4-JAK-STAT6/STAT3 axis, while older remedies such as coal tar and glyteer are antioxidative AHR agonists. Steroids aryl hydrocarbon receptor Homo sapiens