Pub. Date : 2020
PMID : 33232319
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating Nrf2 and HO-1. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Furthermore, Nrf2 and HO-1 mRNA levels, as critical molecules in the oxidative stress pathway, were inhibited by siRNAs targeting MIR4435-2HG, suggesting that MIR4435-2HG-mediated cisplatin resistance occurs through the Nrf2/HO-1 pathway. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Furthermore, Nrf2 and HO-1 mRNA levels, as critical molecules in the oxidative stress pathway, were inhibited by siRNAs targeting MIR4435-2HG, suggesting that MIR4435-2HG-mediated cisplatin resistance occurs through the Nrf2/HO-1 pathway. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |