Title : Fibroblast activation protein-α-adaptive micelles deliver anti-cancer drugs and reprogram stroma fibrosis.

Pub. Date : 2020 Dec 8

PMID : 33231238






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The polymeric micelle is composed of a CD44-targeting shell and a FAP-alpha-cleavable polyethylene glycol (PEG) coating. Polyethylene Glycols fibroblast activation protein alpha Homo sapiens
2 When FAP-alpha is encountered on the surface of CAFs in the tumor microenvironment, the PEG layer is released, hyaluronic acid is recovered on the surface of nanoparticles, and the nanoparticles effectively inhibit the growth of tumor cells and CAFs through CD44-mediated endocytosis. Polyethylene Glycols fibroblast activation protein alpha Homo sapiens