Protein Name fibroblast activation protein alpha
Organism Homo sapiens
Gene ID 2191
Gene Symbol


UniProt Q12884 (SEPR_HUMAN), B4DLR2 (B4DLR2_HUMAN)
Relationships Total Number of functionally related compound(s) : 243
Total Number of Articles : 203

fibroblast activation protein alpha

Gene Summary

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

  • prolyl endopeptidase FAP
  • 170 kDa melanoma membrane-bound gelatinase
  • dipeptidyl peptidase FAP
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