Title : A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.

Pub. Date : 2021 Jan

PMID : 33223341






4 Functional Relationships(s)
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1 A Guillain-Barre syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides. Gangliosides sialic acid binding Ig like lectin 10 Homo sapiens
2 Recombinant Siglec-10 protein containing R47Q but not A108V shows impaired binding to gangliosides. Gangliosides sialic acid binding Ig like lectin 10 Homo sapiens
3 Because Siglec-10 regulates antibody production to sialylated antigens, our finding suggests that Siglec-10 regulates development of GBS by suppressing antibody production to gangliosides, with defects in its function predisposing to disease. Gangliosides sialic acid binding Ig like lectin 10 Homo sapiens
4 Because Siglec-10 regulates antibody production to sialylated antigens, our finding suggests that Siglec-10 regulates development of GBS by suppressing antibody production to gangliosides, with defects in its function predisposing to disease. Gangliosides sialic acid binding Ig like lectin 10 Homo sapiens