Pub. Date : 2021 Feb 5
PMID : 33221536
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When transfected and expressed, ABCA7 also mediates generation of HDL-like particles but small and of less cholesterol content. | Cholesterol | ATP binding cassette subfamily A member 7 | Homo sapiens |
| 2 | In contrast, ABCA7 expression was shown to be regulated negatively by the SREBP system so that decrease of cell cholesterol enhances ABCA7 function such as cellular phagocytotic reaction, suggesting that it links cholesterol metabolism to the host defense system. | Cholesterol | ATP binding cassette subfamily A member 7 | Homo sapiens |
| 3 | In contrast, ABCA7 expression was shown to be regulated negatively by the SREBP system so that decrease of cell cholesterol enhances ABCA7 function such as cellular phagocytotic reaction, suggesting that it links cholesterol metabolism to the host defense system. | Cholesterol | ATP binding cassette subfamily A member 7 | Homo sapiens |
| 4 | In contrast, ABCA7 expression was shown to be regulated negatively by the SREBP system so that decrease of cell cholesterol enhances ABCA7 function such as cellular phagocytotic reaction, suggesting that it links cholesterol metabolism to the host defense system. | Cholesterol | ATP binding cassette subfamily A member 7 | Homo sapiens |
| 5 | Accordingly, modulation of ABCA7 activity by manipulating cholesterol metabolism may open a new path for management of Alzheimer"s disease. | Cholesterol | ATP binding cassette subfamily A member 7 | Homo sapiens |