PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33221536-3 2021 When transfected and expressed, ABCA7 also mediates generation of HDL-like particles but small and of less cholesterol content. Cholesterol 107-118 ATP binding cassette subfamily A member 7 Homo sapiens 32-37 33221536-7 2021 In contrast, ABCA7 expression was shown to be regulated negatively by the SREBP system so that decrease of cell cholesterol enhances ABCA7 function such as cellular phagocytotic reaction, suggesting that it links cholesterol metabolism to the host defense system. Cholesterol 112-123 ATP binding cassette subfamily A member 7 Homo sapiens 13-18 33221536-7 2021 In contrast, ABCA7 expression was shown to be regulated negatively by the SREBP system so that decrease of cell cholesterol enhances ABCA7 function such as cellular phagocytotic reaction, suggesting that it links cholesterol metabolism to the host defense system. Cholesterol 112-123 ATP binding cassette subfamily A member 7 Homo sapiens 133-138 33221536-7 2021 In contrast, ABCA7 expression was shown to be regulated negatively by the SREBP system so that decrease of cell cholesterol enhances ABCA7 function such as cellular phagocytotic reaction, suggesting that it links cholesterol metabolism to the host defense system. Cholesterol 213-224 ATP binding cassette subfamily A member 7 Homo sapiens 13-18 33221536-10 2021 Accordingly, modulation of ABCA7 activity by manipulating cholesterol metabolism may open a new path for management of Alzheimer"s disease. Cholesterol 58-69 ATP binding cassette subfamily A member 7 Homo sapiens 27-32