Title : Dexmedetomidine exerts cardioprotective effect through miR-146a-3p targeting IRAK1 and TRAF6 via inhibition of the NF-κB pathway.

Pub. Date : 2021 Jan

PMID : 33220608






2 Functional Relationships(s)
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1 Dexmedetomidine significantly decreased protein expressions of IRAK1, TRAF6, cleaved Caspase-3, BAX, and NF-kappaB p65, but increased expressions of BCL-2 in H9C2 cells. Dexmedetomidine caspase 3 Rattus norvegicus
2 miR-146a-3p overexpression strengthened the anti-apoptotic effect induced by dexmedetomidine in H9C2 cells via decreasing protein levels of IRAK1, TRAF6, cleaved Caspase-3, BAX, NF-kappaB p65, p-NF-kappaB p65, and p-IkappaBalpha and increasing protein level of BCL-2. Dexmedetomidine caspase 3 Rattus norvegicus