Pub. Date : 2020 Dec 4
PMID : 33211011
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Megadalton-sized Dityrosine Aggregates of alpha-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics. | dityrosine | synuclein alpha | Homo sapiens |
| 2 | Here, we analyze the structural and dynamic properties of megadalton-sized dityrosine adducts of alphaSyn that form in the presence of reactive oxygen species and cytochrome c, a proapoptotic peroxidase that is released from mitochondria during sustained oxidative stress. | dityrosine | synuclein alpha | Homo sapiens |
| 3 | We find that intermolecular dityrosine crosslinks restrict alphaSyn motions only locally whereas large segments of concatenated molecules remain flexible and disordered. | dityrosine | synuclein alpha | Homo sapiens |
| 4 | We further establish that dityrosine adducts inhibit classical amyloid formation by maintaining alphaSyn in its monomeric form and that they are non-cytotoxic despite retaining basic membrane-binding properties. | dityrosine | synuclein alpha | Homo sapiens |