Title : Identifying Insulin Fibril Conformational Differences by Thioflavin-T Binding Characteristics.

Pub. Date : 2020 Dec 14

PMID : 33201685






2 Functional Relationships(s)
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1 In this work, we generate insulin fibrils under four different conditions and attempt to identify distinct conformations using both classic methods, such as atomic force microscopy and Fourier-transform infrared spectroscopy, as well as their ThT binding ability and fluorescence quantum yield. tetrahydrothiophene insulin Homo sapiens
2 We show that there is a significant variance of ThT fluorescence quantum yields, excitation/emission maxima positions, and binding modes between distinct insulin fibril conformations. tetrahydrothiophene insulin Homo sapiens