Title : Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approach.

Pub. Date : 2021 Mar

PMID : 33191904






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1 MATERIALS AND METHODS: An in silico DDI study was conducted using a population-based physiological pharmacokinetic simulator to estimate the CR of cytochrome P450 (CYP)3A4 for zolpidem, sildenafil, omeprazole, triazolam, and repaglinide. Omeprazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens