Title : High-glucose-induced apoptosis, ROS production and pro-inflammatory response in cardiomyocytes is attenuated by metformin treatment via PP2A activation.

Pub. Date : 2020

PMID : 33184242






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1 We found Metformin pre-treatment attenuated human and rat cardiomyocytes apoptosis, HMGB1, TNFalpha and IL-6 release and ROS production that were induced by high-glucose stimulation, and these effects of metformin could be blocked by okadaic acid treatment. Metformin interleukin 6 Rattus norvegicus
2 We found Metformin pre-treatment attenuated human and rat cardiomyocytes apoptosis, HMGB1, TNFalpha and IL-6 release and ROS production that were induced by high-glucose stimulation, and these effects of metformin could be blocked by okadaic acid treatment. Metformin interleukin 6 Rattus norvegicus