Title : [Effect of MDR1 and CYP3A5 gene polymorphisms on outcomes of patients receiving imatinib treatment for chronic myeloid leukemia].

Pub. Date : 2018 Jan 30

PMID : 33177018






3 Functional Relationships(s)
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1 [Effect of MDR1 and CYP3A5 gene polymorphisms on outcomes of patients receiving imatinib treatment for chronic myeloid leukemia]. Imatinib Mesylate ATP binding cassette subfamily B member 1 Homo sapiens
2 OBJECTIVE: To study the effect of MDR1 and CYP3A5 gene polymorphisms on the outcomes of imatinib treatment in patients with chronic myeloid leukemia (CML). Imatinib Mesylate ATP binding cassette subfamily B member 1 Homo sapiens
3 CONCLUSIONS: The risk of cytogenetic relapse of CML was significantly affected by SNPs of C1236T and C3435T loci of MDR1 gene and blood imatinib concentration. Imatinib Mesylate ATP binding cassette subfamily B member 1 Homo sapiens