Title : Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.

Pub. Date : 2021 Mar

PMID : 33168978






1 Functional Relationships(s)
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1 We found that TLAM inhibits phosphofructokinase-1 (PFK1), which in turn activates AMPK-mediated fatty-acid oxidation to promote oxidative phosphorylation, and redirects carbon flow from glycolysis toward the pentose phosphate pathway to reinforce anti-oxidative potential. Fatty Acids protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens