Title : Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-γ/TGF-β1/Smad3 pathway.

Pub. Date : 2021 Jan

PMID : 33162346






3 Functional Relationships(s)
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1 Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathway. bixin toll-like receptor 4 Mus musculus
2 Bixin supplementation inhibited the activation of TLR4, MyD88, NF-kappaB, TGF-beta and Smad3. bixin toll-like receptor 4 Mus musculus
3 Thus, this study demonstrated that Bixin possesses anti-oxidant, anti-inflammatory and anti-fibrosis properties through regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathways. bixin toll-like receptor 4 Mus musculus