Pub. Date : 2020 Nov 4
PMID : 33158207
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Docosahexaenoic Acid Induces Expression of NAD(P)H: Quinone Oxidoreductase and Heme Oxygenase-1 through Activation of Nrf2 in Cerulein-Stimulated Pancreatic Acinar Cells. | Docosahexaenoic Acids | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 2 | In this study, we investigated whether DHA reduces ROS levels and inhibits IL-6 expression via Nrf2 signaling in pancreatic acinar (AR42J) cells stimulated with cerulein, as an in vitro model of acute pancreatitis. | Docosahexaenoic Acids | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | Our results showed that DHA upregulates the expression of NQO1 and HO-1 in cerulein-stimulated AR42J cells by promoting phosphorylation and nuclear translocation of Nrf2. | Docosahexaenoic Acids | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 4 | DHA increased interaction between Keap1 and Nrf2 in AR42J cells, which may increase Nrf2 activity by inhibiting Keap1-mediated sequestration of Nrf2. | Docosahexaenoic Acids | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 5 | DHA increased interaction between Keap1 and Nrf2 in AR42J cells, which may increase Nrf2 activity by inhibiting Keap1-mediated sequestration of Nrf2. | Docosahexaenoic Acids | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 6 | DHA increased interaction between Keap1 and Nrf2 in AR42J cells, which may increase Nrf2 activity by inhibiting Keap1-mediated sequestration of Nrf2. | Docosahexaenoic Acids | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 7 | In conclusion, DHA inhibits ROS-mediated IL-6 expression by upregulating Nrf2-mediated expression of NQO1 and HO-1 in cerulein-stimulated pancreatic acinar cells. | Docosahexaenoic Acids | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 8 | DHA may exert positive modulatory effects on acute pancreatitis by inhibiting oxidative stress and inflammatory cytokine production by activating Nrf2 signaling in pancreatic acinar cells. | Docosahexaenoic Acids | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |