PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33154041-0 2021 Regulation of intestinal UGT1A1 by the FXR agonist obeticholic acid (OCA) is controlled by CAR through intestinal maturation. obeticholic acid 51-67 nuclear receptor subfamily 1, group H, member 4 Mus musculus 39-42 33154041-3 2021 Neonatal humanized UGT1 mice (hUGT1), which accumulate severe levels of total serum bilirubin (TSB), were treated by oral gavage with obeticholic acid (OCA), a potent FXR agonist. obeticholic acid 134-150 nuclear receptor subfamily 1, group H, member 4 Mus musculus 167-170 33154041-12 2021 Thus, new findings link an important role for CAR in intestinal UGT1A1 induction and its role in the intestinal maturation pathway Significance Statement Obeticholic acid (OCA) activates FXR target genes in both liver and intestinal tissues while inducing intestinal UGT1A1 which leads to the elimination of serum bilirubin in hUGT1 mice. obeticholic acid 154-170 nuclear receptor subfamily 1, group H, member 4 Mus musculus 187-190