Title : dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells.

Pub. Date : 2021 Jan

PMID : 33140501






1 Functional Relationships(s)
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1 5-Fluorouracil (5-FU) is an anticancer nucleoside analog that both inhibits thymidylate synthase (TS) and causes DNA damage via the misincorporation of FdUTP and dUTP into DNA under the conditions of dTTP depletion. Nucleosides thymidylate synthetase Homo sapiens