Title : Why Severe COVID-19 Patients Are at Greater Risk of Developing Depression: A Molecular Perspective.

Pub. Date : 2022 Feb

PMID : 33135582






2 Functional Relationships(s)
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1 We posit that a phenomenon known as cytokine storm dramatically activates the enzyme indoleamine 2,3-dioxygenase (IDO-1), resulting in the increase in kynurenine metabolites. Kynurenine indoleamine 2,3-dioxygenase 1 Homo sapiens
2 Kynurenine is metabolized by IDO-1 in the brain, producing chemokines, in which a prolonged exposure may result long-term brain impairment. Kynurenine indoleamine 2,3-dioxygenase 1 Homo sapiens