Title : The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function.

Pub. Date : 2020 Oct 30

PMID : 33126860






1 Functional Relationships(s)
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1 The aim of this study was to determine whether GTS-21 (3-(2,4-dimethoxybenzylidene) anabaseine), an alpha7 nicotinic acetylcholine receptor (alpha7nAChR) agonist, could (1) inhibit hyperoxia-induced HMGB1 release into the airways; (2) enhance macrophage phagocytosis and (3) increase bacterial clearance from the lungs in a mouse model of ventilator-associated pneumonia. 3-(2,4-dimethoxybenzylidene)anabaseine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus