Title : Different Effects of Metformin and A769662 on Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells: Distinct Actions on Mitochondrial Fission and Respiration.

Pub. Date : 2020 Oct 28

PMID : 33126710






1 Functional Relationships(s)
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1 In agreement with the changes on mitochondrial morphology, the ERK-Akt signal axis dependent Drp-1 phosphorylation at S616 (an index of mitochondrial fission) under NaIO3 treatment was blocked by A769662, but not by metformin. Metformin AKT serine/threonine kinase 1 Homo sapiens