Pub. Date : 2021 Apr
PMID : 33125572
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Meanwhile, PXR and its target genes CYP3A4 and P-gp were induced by oridonin, which was associated with the decreased expression of NF-kappaB and the recovery of intestinal barrier. | oridonin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Oridonin Attenuates TNBS-induced Post-inflammatory Irritable Bowel Syndrome via PXR/NF-kappaB Signaling. | oridonin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | In Caco-2 cell lines, oridonin markedly inhibited LPS-induced NF-kappaB activation in a PXR-dependent manner. | oridonin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | This study indicated that the therapeutic effect of oridonin on experimental PI-IBS through repairing intestinal barrier function may be closely associated with the regulatory role of PXR/NF-kappaB signaling pathway. | oridonin | nuclear factor kappa B subunit 1 | Homo sapiens |