Pub. Date : 2020 Oct 29
PMID : 33123800
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study was to investigate the effect of scutellarin on the uptake of rosuvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B3 (hOATP1B3) and rat OATP1B2 (rOATP1B2), respectively, and the effect of scutellarin on the pharmacokinetics of rosuvastatin in rats. | Rosuvastatin Calcium | solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| 2 | RESULTS: Scutellarin inhibited hOATP1B3- and rOATP1B2-mediated rosuvastatin uptake (IC50: 45.54 +- 6.67 muM and 27.58 +- 3.97 muM) in vitro in a concentration-dependent manner. | Rosuvastatin Calcium | solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| 3 | CONCLUSION: Scutellarin may inhibit the hOATP1B3- and rOATP1B2-mediated transport of rosuvastatin in vitro, and exerts a moderate inhibitory effect on the pharmacokinetics of rosuvastatin in rats. | Rosuvastatin Calcium | solute carrier organic anion transporter family member 1B3 | Homo sapiens |